Solutions and films of glycated chitosan
OwnerRobert Nordquist, Raoul Carubelliinventors
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Abstract
Preparations containing glycated chitosan in a physiologically compatible carrier are described. Viscoelastic preparations comprise 1.0-12.0 percent by weight of glycated chitosan in an aqueous solution while lower viscosity solutions possess 0.1-0.5 percent by weight glycated chitosan. The otherwise free amino groups of the chitosan polymer are preferably 30-90% glycated and possess an average molecular weight of between 100,000 and 2,000,000 Daltons, and, most preferably between 100,000 and 1,000,000 Daltons.
Claims8
1-14. (canceled)
An eye drop preparation comprising less than 1 percent by weight of a glycated chitosan polymer dispersed in an aqueous solution, said aqueous solution having a viscosity of between 10-100 centistokes measured at 25° C.
A dried film comprising glycated chitosan.
A medicament for providing the sustained release of a therapeutic substance, comprising glycated chitosan having entrapped therein a desired amount of said therapeutic substance.
A method of preparing ophthalmic wetting agents for topical application to an eye comprising the steps of:
- preparing an aqueous solution having less than 1.0 percent by weight of glycated chitosan and 30% to 90% glycation of otherwise free amino groups of said glycated chitosan;
- wherein said aqueous solution has a viscosity from about 10 centistokes to approximately 100 centistokes.
Dependencies are inferred from the claim text.