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OwnerNobuhiko Kanazashi, Aki Morishita +2inventors
InventorsNobuhiko Kanazashi, Aki Morishita, Osamu Ito, Miki Kurami
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The present invention provides a compound excellent in accumulation on calcified tissues and ensuring rapid excretion into urine as well as rapid clearance from blood, useful as a diagnostic agent and a therapeutic agent, etc. The compound is a compound having affinity with a calcified tissue represented by the following formula: (AC)a-MC-(LI)b. In the formula, MC is a mother nucleus and represents a residue of a compound having a plurality of functional groups selected from the group consisting of an amino group, an amide group, a hydroxyl group, a thiol group, a thioether group, a sulfonyl group, a phosphonyl group, an aldehyde group, a carboxyl group, a carbonyl group, a halogen, and a cyano group; AC is a group having affinity with a calcified tissue; LI is a ligand for binding to a metal atom; and a is an integer of 1 or more and b is 0 or an integer of 1 or more.
A compound having affinity with a calcified tissue represented by the formula:
The compound having affinity with a calcified tissue, represented by the following formula VI-1:
The compound having affinity with a calcified tissue, represented by the following formula VI-2:
The compound having affinity with a calcified tissue, represented by the following formula VII-1:
The compound having affinity with a calcified tissue, represented by the following formula VII-2:
A method of selectively modifying an amino group at a terminal end, which comprises providing an amino oligosaccharide having 2 to 50 saccharide units which consists of one or more monosaccharides selected from the group consisting of glucosamine, mannosamine and galactosamine and is reduced at a terminal end thereof, and subjecting the amino oligosaccharide to a reaction for generating a carbamate compound.
A method of selectively modifying an amino group at a terminal end with a butoxycarbonyl (Boc) group, which comprises reacting, dibutyl dicarbonate, an aminosaccharide of 2 to 13 saccharide units which consists of one or more monosaccharides selected from the group consisting of glucosamine, mannosamine and galactosamine and reduced at a terminal end thereof.
Dependencies are inferred from the claim text.