Methods and sequences to suppress pro-inflamatory cytokine actions locally to treat pain
AssigneeMedtronic, Inc.
InventorsEric Burright, Rodolfo Padua, Peter Schroeder, Jennifer Christianson, Lisa Shafer
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods and sequences used to treat pain. Specifically, the methods and sequences include locally administering nucleic acid molecules that suppress the expression of amino acid sequences that encode for pro-inflammatory cytokines and their receptors to treat acute or neuropathic pain associated with sciatica.
Claims44
A method of treating pain comprising:
- administering locally nucleic acid molecules comprising one or more sequences that suppress the expression of amino acid sequences encoding for pro-inflammatory cytokines and/or pro-inflammatory cytokine receptors wherein said sequences are selected from the group consisting of SEQ ID NO:
- 14;
- SEQ ID NO:
- 15;
- SEQ ID NO:
- 16;
- SEQ ID NO:
- 17;
- SEQ ID NO:
- 18;
- SEQ ID NO:
- 19;
- SEQ ID NO:
- 20;
- SEQ ID NO:
- 21;
- SEQ ID NO:
- 23;
- SEQ ID NO:
- 24;
- SEQ ID NO:
- 25;
- SEQ ID NO:
- 26;
- SEQ ID NO:
- 27;
- SEQ ID NO:
- 28;
- SEQ ID NO:
- 29;
- SEQ ID NO:
- 30;
- SEQ ID NO:
- 31;
- SEQ ID NO:
- 32;
- SEQ ID NO:
- 33;
- SEQ ID NO:
- 34;
- SEQ ID NO:
- 35;
- SEQ ID NO:
- 36;
- SEQ ID NO:
- 37;
- SEQ ID NO:
- 38;
- SEQ ID NO:
- 39;
- SEQ ID NO:
- 40;
- SEQ ID NO:
- 41;
- SEQ ID NO:
- 42;
- SEQ ID NO:
- 43;
- SEQ ID NO:
- 44;
- SEQ ID NO:
- 45;
- SEQ ID NO:
- 46 and combinations thereof.
A method of treating pain comprising:
- administering locally nucleic acid molecules comprising one or more sequences that suppress the expression of amino acid sequences encoding for pro-inflammatory cytokines and/or pro-inflammatory cytokine receptors wherein said local administration occurs through a form selected from one or more of the group consisting of a catheter and drug pump, one or more local injections and polymer release.
A nucleic acid molecule used to treat pain locally comprising a nucleotide sequence comprising one or more sequences that suppress the expression of amino acid sequences encoding for pro-inflammatory cytokines and/or pro-inflammatory cytokine receptors wherein said sequences are selected from the group consisting of SEQ ID NO:
- 14;
- SEQ ID NO:
- 15;
- SEQ ID NO:
- 16;
- SEQ ID NO:
- 17;
- SEQ ID NO:
- 18;
- SEQ ID NO:
- 19;
- SEQ ID NO:
- 20;
- SEQ ID NO:
- 21;
- SEQ ID NO:
- 23;
- SEQ ID NO:
- 24;
- SEQ ID NO:
- 25;
- SEQ ID NO:
- 26;
- SEQ ID NO:
- 27;
- SEQ ID NO:
- 28;
- SEQ ID NO:
- 29;
- SEQ ID NO:
- 30;
- SEQ ID NO:
- 31;
- SEQ ID NO:
- 32;
- SEQ ID NO:
- 33;
- SEQ ID NO:
- 34;
- SEQ ID NO:
- 35;
- SEQ ID NO:
- 36;
- SEQ ID NO:
- 37;
- SEQ ID NO:
- 38;
- SEQ ID NO:
- 39;
- SEQ ID NO:
- 40;
- SEQ ID NO:
- 41;
- SEQ ID NO:
- 42;
- SEQ ID NO:
- 43;
- SEQ ID NO:
- 44;
- SEQ ID NO:
- 45;
- SEQ ID NO:
- 46 and combinations thereof.
A system comprising:
- nucleic acid molecules comprising one or more sequences that suppress the expression of amino acid sequences encoding for pro-inflammatory cytokines and/or pro-inflammatory cytokine receptors wherein said sequences are selected from the group consisting of SEQ ID NO:
- 14;
- SEQ ID NO:
- 15;
- SEQ ID NO:
- 16;
- SEQ ID NO:
- 17;
- SEQ ID NO:
- 18;
- SEQ ID NO:
- 19;
- SEQ ID NO:
- 20;
- SEQ ID NO:
- 21;
- SEQ ID NO:
- 23;
- SEQ ID NO:
- 24;
- SEQ ID NO:
- 25;
- SEQ ID NO:
- 26;
- SEQ ID NO:
- 27;
- SEQ ID NO:
- 28;
- SEQ ID NO:
- 29;
- SEQ ID NO:
- 30;
- SEQ ID NO:
- 31;
- SEQ ID NO:
- 32;
- SEQ ID NO:
- 33;
- SEQ ID NO:
- 34;
- SEQ ID NO:
- 35;
- SEQ ID NO:
- 36;
- SEQ ID NO:
- 37;
- SEQ ID NO:
- 38;
- SEQ ID NO:
- 39;
- SEQ ID NO:
- 40;
- SEQ ID NO:
- 41;
- SEQ ID NO:
- 42;
- SEQ ID NO:
- 43;
- SEQ ID NO:
- 44;
- SEQ ID NO:
- 45;
- SEQ ID NO:
- 46 and combinations thereof and wherein said system is used to treat pain locally.
A system comprising nucleic acid molecules comprising one or more sequences that suppress the expression of amino acid sequences encoding for pro-inflammatory cytokines and/or pro-inflammatory cytokine receptors wherein said sequences are locally administered through one or more of the group consisting of a catheter and drug pump, one or more local injections and polymer release.
A kit for treating pain comprising:
- nucleic acid molecules comprising one or more sequences that suppress the expression of amino acid sequences encoding for pro-inflammatory cytokines and/or pro-inflammatory cytokine receptors wherein said sequences are selected from the group consisting of SEQ ID NO:
- 14;
- SEQ ID NO:
- 15;
- SEQ ID NO:
- 16;
- SEQ ID NO:
- 17;
- SEQ ID NO:
- 18;
- SEQ ID NO:
- 19;
- SEQ ID NO:
- 20;
- SEQ ID NO:
- 21;
- SEQ ID NO:
- 23;
- SEQ ID NO:
- 24;
- SEQ ID NO:
- 25;
- SEQ ID NO:
- 26;
- SEQ ID NO:
- 27;
- SEQ ID NO:
- 28;
- SEQ ID NO:
- 29;
- SEQ ID NO:
- 30;
- SEQ ID NO:
- 31;
- SEQ ID NO:
- 32;
- SEQ ID NO:
- 33;
- SEQ ID NO:
- 34;
- SEQ ID NO:
- 35;
- SEQ ID NO:
- 36;
- SEQ ID NO:
- 37;
- SEQ ID NO:
- 38;
- SEQ ID NO:
- 39;
- SEQ ID NO:
- 40;
- SEQ ID NO:
- 41;
- SEQ ID NO:
- 42;
- SEQ ID NO:
- 43;
- SEQ ID NO:
- 44;
- SEQ ID NO:
- 45;
- SEQ ID NO:
- 46 and combinations thereof and an administration form that locally delivers said nucleic molecules.
A kit comprising nucleic acid molecules comprising one or more sequences that suppress the expression of amino acid sequences encoding for pro-inflammatory cytokines and/or pro-inflammatory cytokine receptors and a delivery form selected from one or more of the group consisting of a catheter and drug pump, one or more local injections and polymer release wherein said delivery form is used to administer said nucleic molecules locally to treat pain.
Dependencies are inferred from the claim text.