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US 2006/0189561 A1Published application
RNAi expression constructs with liver-specific enhancer/promoter
AssigneeBenitec, Inc.
InventorsPetrus Roelvink, David Suhy, Alexander Kolykhalov, Mark Kay, Jeffery Giering
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Abstract
The present invention provides compositions and methods suitable for RNAi specifically in the liver so as to treat diseases or disorders.
Claims20
An expression construct comprising:
- one or more enhancer elements selected from the group consisting of ApoE enhancer elements and SynEnh enhancer elements;
- one or more liver-specific promoters;
- and
- one or more RNAi constructs that provide one or more RNAi agents.
1 more element
A method of modifying the expression of one or more genes in the liver, comprising delivering to the liver an expression construct comprising:
- one or more enhancer elements selected from the group consisting of ApoE enhancer elements and SynEnh enhancer elements;
- one or more liver-specific promoters;
- and
- one or more RNAi constructs that provide one or more RNAi agents.
1 more element
Dependencies are inferred from the claim text.