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US 2006/0189557 A1Published application
Regulation of oncogenes by microRNAs
AssigneeYale University
InventorsFrank Slack, Steven Johnson, Helge Grosshans
Life of this patent
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AssigneeYale University
InventorsFrank Slack, Steven Johnson, Helge Grosshans
Estimating the term…
Naturally occurring miRNAs that regulate human oncogenes and methods of use therof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions containing nucleic acids are administered to a patient in need of treatment or prophylaxis of at least one symptom or manifestation of cancer. In one embodiment, the compositions are administered in an effective amount to inhibit gene expression of one or more oncogenes. Methods for treatment or prevention of at least one symptom or manifestation of cancer are also described.
A method for inhibiting the expression of one or more oncogenes comprising
A method for determining the sensitivity of a cancer to an miRNA comprising providing an miRNA, or increasing expression of the miRNRA, that binds to an oncogene in cancerous or transformed cells or an organism with cancerous or transformed cells and determining if the cancerous or transformed cell growth or viability is inhibited of if expression of the oncogene is inhibited.
A therapeutic composition for inhibiting the expression of one or more oncogenes comprising an effective amount of miRNA to bind to and exhibit expression of an oncogene in transformed or cancerous cells in an organism and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.