DNA cancer vaccines
AssigneeNational Defense Medical Center, National Defense University
InventorsDah-Shyong Yu, Sun-Yran Chang, Chi-Feng Lee
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Abstract
A plurality of DNA cancer vaccines and their uses in treating cancer are disclosed. Genes encoding Mycobacterium bovis bacillus Calmette-Guérin (M. bovis BCG) recombinant antigens and genes encoding interlukin-12 heterodimer were respectively cloned into eukaryotic expression vectors to express the encoded recombinant proteins in mammalian cells in vivo whereby specific immune responses are evoked and are effective in preventing, attenuating and/or suppressing the growth of a tumor.
Claims22
A DNA cancer vaccine comprises a plasmid vector comprising a polynucleotide sequence encoding at least two mycobacterial antigens operably linked to transcription regulatory elements, wherein upon administration to a mammal, said DNA cancer vaccine can effectively attenuate or suppress the growth of cancer cells.
A DNA cancer vaccine comprises a plasmid vector comprising a polynucleotide sequence encoding a heterodimeric protein of Interleukin-12 operably linked to transcription regulatory elements, wherein upon administration to a mammal, said DNA vaccine can effectively attenuate or suppress the growth of cancer cells.
A composition for treating cancers comprises at least four DNA cancer vaccines, wherein each of said DNA cancer vaccines comprises a first plasmid vector comprising a nucleotide sequence encoding at least two mycobacterial antigens;
- and wherein upon administration to a mammal, said composition can effectively attenuate or suppress the growth of cancer cells.
Dependencies are inferred from the claim text.