Novel chemical entities and methods for their use in treatment of metabolic disorders
OwnerSamuel Henderson, Steve Orndorff +1inventors
InventorsSamuel Henderson, Steve Orndorff, Lawrence Melvin
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Abstract
Methods and composition for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of novel esterified saccharide compounds to said patient at a level to produce an improvement in cognitive ability.
Claims15
A compound of the formula:
- wherein A represents a saccharide moiety, p is the number of free hydroxyl groups on the saccharide moiety A, and R1 is independently selected from a fatty acid residue having 5-12 carbons in the carbon backbone (C5 to C12 fatty acids) esterified to the saccharide, a saturated fatty acid residue having 5-12 carbons in the carbon backbone (C5 to C12 fatty acids) esterified to the saccharide, an unsaturated fatty acid residue having 5-12 carbons in the carbon backbone (C5 to C12 fatty acids) esterified to the saccharide, and derivatives of any of the foregoing, and wherein the compound is not described in Takada, et al., 1991 nor Jandacek & Webb, 1978.
A compound of the formula:
- wherein R2 is independently selected from the group consisting of R1, an essential fatty acid esterified to the saccharide, β-hydroxybutyrate esterified to the saccharide, acetoacetate esterified to the saccharide, compound 5 esterified to the saccharide, and compound 6 esterified to the saccharide, and wherein the compound is not described in Takada, et al., 1991 nor Jandacek & Webb, 1978.
A pharmaceutical composition, comprising a TCA cycle intermediate and a compound selected from the group consisting of a compound of the formula
- wherein A represents a saccharide moiety, p is the number of free hydroxyl groups on the saccharide moiety A, and R1 is independently selected from a fatty acid residue having 5-12 carbons in the carbon backbone (C5 to C12 fatty acids) esterified to the saccharide, a saturated fatty acid residue having 5-12 carbons in the carbon backbone (C5 to C12 fatty acids) esterified to the saccharide, an unsaturated fatty acid residue having 5-12 carbons in the carbon backbone (C5 to C12 fatty acids) esterified to the saccharide, and derivatives of any of the foregoing;
- and a compound of the formula:
- wherein R2 is independently selected from the group consisting of R1, an essential fatty acid esterified to the saccharide, β-hydroxybutyrate esterified to the saccharide, acetoacetate esterified to the saccharide, compound 5 esterified to the saccharide, and compound 6 esterified to the saccharide.
15-38. (canceled)
Dependencies are inferred from the claim text.