Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf)
OwnerKarl Volz, Stephanie Filleur +2inventors
InventorsKarl Volz, Stephanie Filleur, Olga Volpert, Tetiana Zaichuk
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Abstract
The present invention provides anti-angiogenic derived from pigment epithelium-derived factor (PEDF) pharmaceutical compositions comprising the peptides, and methods of preventing angiogenesis. Such methods are useful in treating angiogenesis-associated disorders and diseases.
Claims21
An anti-angiogenic pigment epithelium-derived factor (PEDF) fragment, the anti-angiogenic peptide having an amino acid sequence consisting essentially of 5-50 contiguous amino acids of SEQ ID NO:1.
A method of inhibiting endothelial cell migration or proliferation comprising contacting an endothelial cell with a composition comprising an effective amount of a pigment epithelium-derived factor (PEDF) peptide fragment, wherein the PEDF peptide fragment has anti-angiogenic activity.
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A method of treating cancer comprising administering a therapeutically effective amount of an anti-angiogenic pigment epithelium-derived factor (PEDF) fragment to a patent in need thereof.
A method of treating an opthalmological disease of disorder comprising administering a therapeutically effective amount of an anti-angiogenic pigment epithelium-derived factor (PEDF) fragment to a patent in need thereof.
A method of predicting whether a diabetic patient will develop proliferative retinopathy comprising determining the ratio of vascular endothelial growth factor (VEGF) to PEDF in an ocular fluid sample from said patient.
Dependencies are inferred from the claim text.