Preventing/remedies for cancer
AssigneeTakeda Pharmaceutical Company Limited
InventorsHiroshi Tanaka, Isao Kaieda, Kohei Honda
Life of this patent
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Abstract
The invention provides prophylactic/therapeutic agent for cancer, etc. More specifically, a compound or its salt inhibiting the activity f a protein having an amino acid sequence, which is the same or substantially the same amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 16, a compound or its salt inhibiting the expression of a gene for the above protein, an antisense nucleotide containing a base sequence or a part thereof, which is complementary or substantially complementary to the base sequence of a DNA encoding the above protein or its partial peptide, an antibody to the above protein or its partial peptide, etc. are usable as a prophylactic/therapeutic agent for cancer, and so on.
Claims33
A prophylactic/therapeutic agent for cancer, comprising a compound or its salt inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
A prophylactic/therapeutic agent for cancer, comprising a compound or its salt inhibiting the expression of a gene for a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
An antisense polynucleotide comprising the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
An antibody to a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
A diagnostic agent comprising a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
A prophylactic/therapeutic agent for cancer comprising a compound or its salt inhibiting the activity of ELOVL2.
A prophylactic/therapeutic agent for cancer comprising a compound or its salt inhibiting the expression of ELOVL2.
A method of screening a prophylactic/therapeutic agent for cancer, which comprises using a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
A kit for screening a prophylactic/therapeutic agent for cancer, which comprises a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
(canceled)
A method of screening a prophylactic/therapeutic agent for cancer, which comprises using a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
A kit for screening a prophylactic/therapeutic agent for cancer, which comprises a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
(canceled)
An apoptosis promoting agent comprising a compound or its salt inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
An apoptosis promoting agent comprising a compound or its salt inhibiting the expression of a gene for a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
A method of screening an apoptosis promoter, which comprises using a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
A method of screening an apoptosis promoter, which comprises using a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
A method of preventing/treating cancer, which comprises administering to a mammal an effective dose of a compound or its salt inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof, or an effective dose of a compound or its salt inhibiting the expression of a gene for the protein.
A method of preventing/treating cancer, which comprises inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof, or inhibiting the expression of a gene for the protein.
33-66. (canceled)
Dependencies are inferred from the claim text.