Molecules for transporting a compound across the blood-brain barrier
AssigneeAngiochem Inc.
InventorsRichard Beliveau, Michel Demeule, Christian Che, Anthony Regina
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Abstract
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptide derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides. The present invention also relates to the use of these polypeptide for transporting a compound or drug across the blood-brain barrier of an individual and in the treatment and diagnosis of neurological diseases.
Claims43
A biologically active polypeptide able to cross a cell layer mimicking a mammalian blood brain barrier in an in vitro assay, said polypeptide being selected from the group of;
- a) an aprotinin fragment comprising the amino acid sequence defined in SEQ ID NO.:1,
- b) an aprotinin fragment consisting of SEQ ID NO.:1,
- c) a biologically active analogue of SEQ ID NO.:1,
- d) a biologically active fragment of SEQ ID NO.:1, and;
- e) a biologically active fragment of a SEQ ID NO.:1 analogue.
Dependencies are inferred from the claim text.