Compositions and uses of a galectin for treatment of dry eye syndrome
AssigneeTrustees of Tufts College
InventorNoorjahan Panjwani
Life of this patent
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Abstract
Methods for the therapeutic treatment of dry eye in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-1 protein, a galectin-3, a galectin-7 protein and/or a galectin-8 protein are provided. Pharmaceutical and ophthalmic compositions and kits, comprising a pharmaceutically an active agent which is a galectin-1 protein, a galectin-3 protein, galectin-7 protein and/or a galectin-8 protein, and a suitable carrier or a diluent, are provided.
Claims57
A method for treating or preventing dry eye in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a galectin protein.
A pharmaceutical composition having a promoting effect on treatment of dry eye, the composition comprising a pharmaceutically suitable carrier or diluent and an amount of at least one galectin selected from galectin-1, galectin-3, galectin-7, and galectin-8 protein sufficient to promote integrity of conjunctival and/or corneal epithelia.
A method for treating dry eye disease in a mammal in need thereof, comprising administering to a mammal a therapeutically effective amount of a substance that influences the spreading of tear film onto the corneal surface or conjunctival surface.
A method for treating dry eye disease in a mammal in need thereof, comprising administering to a mammal afflicted with a dry eye a therapeutically effective amount of a substance that influences the expression of at least one protein selected from of the group of galectin-1, galectin-3, galectin-7, and galectin-8.
A kit for treating dry eye comprising a container, at least one protein selected from of the group of galectin-1, galectin-3, galectin-7, and galectin-8 in a pharmaceutically suitable carrier or diluent, and instructions for use.
Dependencies are inferred from the claim text.