US 2006/0189511 A1 · Method for cytoprotection through mdm2 and hdm2 inhibition

Abstract

The present invention is directed to a method of protecting one or more cells from programmed cytotoxic cell death by contacting the cells with a cytoprotective amount of an MDM2 and/or HDM2 inhibitor. The cytoprotective amount of inhibitor is typically used as a pulsed administration. Useful inhibitors include a class of 1,4-benzodiazepines, which act as inhibitors of MDM2-p53 interactions. The method of the invention can be employed as an adjunct to chemotherapy or radiation therapy. In addition, the methods of the invention can be employed to treat a disease or condition that involves excessive cell death.

Claims10

Dependent claims

An integrated laser communications control system (200) comprising:

a modulation drive signal (300),
a driver (301),
a digital laser controller IC (320),
a set of sensors (306, 307, 309, 319), and
a Laser Module (303),
wherein control methods control the various operational parameters of the Laser Module (303), wherein the control first starts with a modulation drive signal (300) causing the driver (301) to send an appropriate signal to an output (302) so that a laser can send an optical power output (304) proportional to a modulation drive signal (300), and further wherein the control methods embedded in a digital laser controller IC (320) consist of control algorithms embedded in firmware.

3 more elements

In firmware of an integrated laser communications controller (320), a method of operation comprising the steps of

receiving a modulation drive signal (300), and
orchestrating control of the firmware in a transceiver real time operating system (516), wherein the real time operating system (516) further comprises the steps of:
controlling the execution of programs and routines,
forming an open drive interface for various user application programs,
configuring of the operating system (516),
passing parameters,
connecting special programs from the user to the transceiver controls, and
utilizing drivers and utilities, wherein the operating system is further responding to requests of servo systems in a prescribed period of time so that control variables do not drift away from a desired set point.

5 more elements

Dependencies are inferred from the claim text.

Method for cytoprotection through mdm2 and hdm2 inhibition

Life of this patent

Method for cytoprotection through mdm2 and hdm2 inhibition

Life of this patent

Abstract

Claims10