Novel prostate tumor-specific promoter
AssigneeSchering Corporation
InventorsPeter Kretschmer, Gordon Parry, Pamela Van Heuit, Ta-Tung Yuan
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Abstract
This invention provides novel transcriptional regulatory elements from the human TRPM4 (Transient Receptor Potential-Melastatin 4) gene. These promoter and enhancer elements preferentially activate transcription in prostate tumor cells and tissues as compared to other tissues. Methods and compositions are provided to employ TRPM4 promoter elements for prostate tumor-specific expression of therapeutic molecules. Prostate tumor-restricted replicating adenoviral vectors are also provided.
Claims21
An isolated polynucleotide comprising a TRPM4 (transient receptor potential-melastatin 4) promoter polynucleotide, wherein the TRPM4 promoter polynucleotide is at least 70% identical to SEQ ID NO:
- 1 over a stretch of at least 70 nucleotides and confers prostate tumor-specific transcription when operably linked to a heterologous polynucleotide.
Dependencies are inferred from the claim text.