3'-phosphoadenosine-5'-phosphosulfate synthetase 1 (PAPSS1) sequence variants
AssigneeMayo Foundation for Medical Education and Research, a Minnesota corporation
InventorsZhenhua Xu, Eric Wieben, Richard Weinshilboum
Life of this patent
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Abstract
Isolated PAPSS1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PAPSS1 allozymes. Methods for determining if a mammal is predisposed to joint disease or cancer also are described.
Claims3
An isolated PAPSS1 polypeptide, wherein said polypeptide comprises a PAPSS1 amino acid sequence variant relative to the amino acid sequence of SEQ ID NO:14, wherein said amino acid sequence variant is at a residue selected from the group consisting of 333 and 531.
Dependencies are inferred from the claim text.