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US 2006/0188972 A1Published application
Targeted modification of chromatin structure
AssigneeSangamo BioSciences, Inc.
InventorAlan Wolffe
Life of this patent
Estimating the term…
Abstract
Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
Claims7
A polynucleotide encoding a fusion polypeptide, wherein the fusion polypeptide comprises:
- (a) a DNA-binding domain;
- and
- (b) a component of a chromatin remodeling complex or a functional fragment thereof.
Dependencies are inferred from the claim text.