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US 2006/0188971 A1Published application
Urate oxidase
AssigneeDuke University
InventorsMichael Hershfield, Susan Kelly
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Abstract
The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.
Claims1
A protein comprising a recombinant uricase protein of a mammalian species which has been modified to insert one or more lysine residues.
Dependencies are inferred from the claim text.