Novel TNF receptor death domain ligand proteins and inhibitors of ligand binding
OwnerLih-Ling Lin, Jennifer Chen +2inventors
InventorsLih-Ling Lin, Jennifer Chen, Andrea Schievella, James Graham
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Abstract
Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
Claims16
1-46. (canceled)
A method of preventing or ameliorating an inflammatory disorder by administering to a mammal an antibody which specifically binds to a protein with the amino acid sequence of SEQ NO:2 or a fragment of said antibody.
A method of preventing or ameliorating an inflammatory disorder by administering to a mammal a neutralizing antibody that binds specifically to a protein with the amino acid sequence of SEQ ID NO:2, wherein said neutralizing antibody blocks binding of TNF-R1-DD to a TNF-R1-DD ligand protein with the amino acid sequence of SEQ ID NO:2, or a fragment of said neutralizing antibody.
A method of preventing or ameliorating an inflammatory disorder by administering to a mammal an antibody that specifically binds to a protein with the amino acid sequence of SEQ ID NO:2, wherein said antibody is obtained using as an immunogen TNF-R1-DD ligand protein with the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.