G-protein estrogen membrane receptor
AssigneeBoard of Regents, The University of Texas System
InventorsPeter Thomas, Yefei Pang, Edward Filardo
Life of this patent
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Abstract
The present invention includes compositions and methods for the identification, isolation and characterization of a G-protein-coupled receptor that binds to an estrogen or estrogen-like molecule, to modulators of the receptor's activity and diagnostic methods for use in detection and treatment of a G-protein-coupled receptor related cancer.
Claims34
A composition comprising an isolated and purified G-protein-coupled receptor that binds specifically to an estrogen.
An isolated polypeptide encoded by the nucleic acid fragment of SEQ ID NO.:1, GenBank;
- accession No. BC011634.
A method of identifying a test compound that modulates the binding of an estrogen to a G-protein-coupled receptor comprising the step of measuring binding of an estrogen to a G-protein receptor to the estrogen in the presence and absence of a test compound, wherein the test compound modulates the binding of the estrogen to the G-protein receptor and is indicative that the test compound is a modulator of the binding of the estrogen to the G-protein receptor.
A vector comprising the nucleic acid sequence of SEQ ID NO.:1, GenBank;
- accession No. BC011634.
A host cell comprising a vector comprising the nucleic acid sequence of SEQ ID NO.:1, GenBank;
- accession No. BC011634.
A method of treating cancer, comprising the steps of:
- identifying a patient in need of cancer therapy;
- and
- providing to the patient an effective dose of a GPCR modulator.
A method of diagnostic a condition related to nonclassical estrogen binding, comprising the step of binding a GPCR binding agent comprising a detectable label to a cell.
A dosage form comprising a therapeutically effective amount of an estrogen or estrogen derivative that is specific for a GPCR.
A method of identifying a GCPR modulator comprising the steps of:
- screening a compound library for one or more agents that bind to a membrane-associated G-protein estrogen receptor.
An isolated and purified membrane-associated G-protein estrogen receptor.
A diagnostic method comprising the steps of:
- characterizing the expression of an isolated and purified membrane-associated G-protein estrogen receptor of a patient, and
- treating the patient with an agent that modifies the activity of the membrane-associated G-protein estrogen receptor.
Dependencies are inferred from the claim text.