Novel human parvovirus B19 receptor and uses thereof
OwnerYasuhiko Munakata, Takako Saitoinventors
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Abstract
A novel receptor for human parvovirus B19, other than P antigen, as well as a reagent for measuring human parvovirus B19, a reagent for adsorbing human parvovirus B19, and an agent for suppressing infection, which utilize the receptor for human parvovirus B19 is disclosed. It was discovered that Ku 80 protein is a receptor for human parvovirus B19. Thus, a receptor for human parvovirus B19 consisting essentially of Ku80 was provided. The agent for binding human parvovirus B19 comprises Ku80. The agent for suppressing infection by human parvovirus B19 comprises a substance which inhibits the binding between Ku80 and human parvovirus B19 or a binding fragment thereof.
Claims14
A method for binding human parvovirus B19 comprising:
- bringing a receptor for human parvovirus B19 into contact with human parvovirus B19;
- wherein said receptor consists essentially of a protein having the amino acid sequence shown in SEQ ID NO:1, or a protein having an amino acid sequence having a homology of not less than 90% with the amino acid sequence shown in SEQ ID NO:1.
A method for measuring human parvovirus B19 comprising the step of:
- binding a receptor for human parvovirus B19 and human parvovirus B19;
- wherein said receptor consists essentially of a protein having the amino acid sequence shown in SEQ ID NO:1, or a protein having an amino acid sequence having a homology of not less than 90% with the amino acid sequence shown in SEQ ID NO:1.
A method for adsorbing human parvovirus B19 comprising:
- bringing human parvovirus B19 in a sample into contact with immobilized receptor for human parvovirus B19;
- wherein said receptor consists essentially of a protein having the amino acid sequence shown in SEQ ID NO:1, or a protein having an amino acid sequence having a homology of not less than 90% with the amino acid sequence shown in SEQ ID NO:1.
Dependencies are inferred from the claim text.