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US 2006/0188916 A1Published application
Peptoids incorporating chemoselective functionalities
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsThomas Horn, Ronald Zuckermann
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Abstract
Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.
Claims10
A hydrophilic spacer group-molecule conjugate having the structure:
- where
- Y is NH, O, or S,
- each of m and n is independently 2 to 6;
- A is S or Se,
- p is 1 to 100,
- one of X and Z is a terminating group or ligation moiety, and the other is a molecule selected from a peptoid, a peptide, an oligonucleotide, and an oligosaccharide, joined to said spacer group via an optional linking group.
3 more elements
Dependencies are inferred from the claim text.