Business methods for assessing nucleic acids
AssigneesMedical College of Ohio, Gene Express, Inc.
InventorsJames Willey, Brad Austermiller, Erin Crawford, Charles Knight, Terry Osborn, Robert Zahorchak
Life of this patent
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Abstract
The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions and methods. In particular, the present invention provides business methods for operating a gene expression measurement service.
Claims44
A business method comprising:
- collecting a first specimen comprising a first nucleic acid;
- measuring an amount of said first nucleic acid in a first sample of said first specimen wherein said measuring can enumerate less than about 1,000 molecules of said first nucleic acid in said first sample;
- and
- providing said amount as a numerical value wherein said numerical value allows direct comparison to an amount of said first nucleic acid in a second sample.
A business method of improving drug development, comprising:
- collecting a first specimen comprising a nucleic acid from a first biological entity administered a candidate drug at first stage of drug development;
- collecting a second specimen comprising said nucleic acid from a second biological entity at a second stage of drug development;
- assessing an amount of said nucleic acid in each of said first and said second specimen;
- directly comparing said amounts;
- and
- altering a step of said drug development based on said comparison.
A business method of improving drug development, comprising:
- providing a database comprising numerical values corresponding to amounts of a first nucleic acid in a number of samples wherein said numerical values are directly comparable between 5 of said samples;
- collecting a first specimen comprising said first nucleic acid from a biological entity administered a candidate drug at a stage of drug development;
- assessing an amount of said first nucleic acid in a first sample of said first specimen;
- directly comparing said amount to at least one of said numerical values in said database;
- and
- altering a step of said drug development based on said comparison.
A business method of improving drug development, comprising:
- providing a database comprising numerical indices, said numerical indices obtained by mathematical computation of 2 numerical values corresponding to amounts of 2 nucleic acids in a number of samples wherein said numerical indices are directly comparable between 5 of said samples;
- collecting a first specimen comprising said 2 nucleic acids from a biological entity administered a candidate drug at a stage of drug development;
- assessing an amount of each of said 2 nucleic acids in a first sample of said first specimen;
- using said 2 amounts to mathematically compute a first numerical index;
- directly comparing said first numerical index to at least one of said numerical indices in said database;
- and
- altering a step of said drug development based on said comparison.
Dependencies are inferred from the claim text.