Binding a target substance
AssigneeSinvent Ventures A S
InventorsLars Kilaas, Anne Dyrli, Vidar Skagestad
Life of this patent
Estimating the term…
Abstract
Magnetic particles capable of binding a target substance, which comprise a magnetic material and a matrix material, wherein the magnetic material is remanent upon exposure to a magnetic field and the matrix material has a surface comprising functional groups which promote disaggregation of the particles in the presence of a liquid phase.
Claims55
Magnetic particles capable of binding a target substance, which comprise a magnetic material and a matrix material, wherein the magnetic material is remanent upon exposure to a magnetic field and the matrix material has a surface comprising functional groups which promote disaggregation of the particles in the presence of a liquid phase.
Magnetic particles according to clam 16, wherein the affinant comprises a binding protein which comprises an avidin for binding to a target substance which, is biotinylated, or the affinant comprises biotin and the target substance is avidinylated.
A process for the preparation of magnetic particles capable of binding a target substance, which comprises providing an unmagnetised magnetic material, and providing a matrix material so as to form magnetic particles, wherein the magnetic material is remanent upon exposure to a magnetic field and the matrix material has a surface comprising functional groups which promote disaggregation of the particles in the presence of a liquid phase.
A process for separating a target substance from a target substance containing sample, which comprises:
- (a) providing target substance binding magnetic particles which comprise a magnetic material and a matrix material, wherein the magnetic material is remnant upon exposure to a magnetic field;
- (b) providing a liquid phase comprising the target substance-containing sample;
- (c) dispersing the sample with the magnetic particles so as to bind the target substance thereto;
- and
- (d) isolating the particles from the sample by applying a magnetic field thereto and separating the particles from the liquid phase.
Dependencies are inferred from the claim text.