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US 2006/0188866 A1Published application
Diaminophenothiazine compositions and uses thereof
AssigneeChildren's Hospital Oakland Research Institute
InventorsHani Atamna, Bruce Ames
Life of this patent
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Abstract
Cell senescence is delayed by contacting a cell specifically determined to be in need of delayed cell senescence with an effective amount of a diaminophenothiazine.
Claims21
A method for delaying cell senescence, the method comprising the step of:
- contacting a cell specifically determined to be in need of delayed cell senescence with an effective amount of a diaminophenothiazine;
- wherein the diaminophenothiazine has the structure:
- and tautomeric forms thereof, wherein R1, R2, R3, R4, R5, R6, R1′, R2′, R3′, and R4′ are independently hydrogen, methyl or ethyl,
- wherein the cell is a mitotically active cell in vitro in a culture medium comprising 1-1000 nM diaminophenothiazine, and the contacting step comprises culturing the cell in the medium for at least one week.
1 more element
A method for delaying cell senescence, the method comprising the step of:
- contacting a cell specifically determined to be in need of delayed cell senescence with an effective amount of a diaminophenothiazine;
- wherein the diaminophenothiazine has the structure:
- and tautomeric forms thereof, wherein R1, R2, R3, R4, R5, R6, R1′, R2′, R3′, and R4′ are independently hydrogen, methyl or ethyl,
- wherein the cell is in situ in an individual, and the contacting step comprises chronically orally administering to the individual a dosage of 5-500 μg per day of the diaminophenothiazine to provide said effective amount.
1 more element
21-36. (canceled)
Dependencies are inferred from the claim text.