Method for the purification of sucralose
OwnerGreg Liesen, Sunil Srivastavainventors
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Abstract
This invention relates to the purification of sucralose by contacting a mixture containing crude sucralose with organic and/or aqueous organic solvents. The mixture may be crystallized from aqueous organic solvents using pure sucralose seed crystals.
Claims51
A process for purifying a sucralose mixture comprising sucralose, polar impurities and non-polar impurities, the process comprising the steps of:
- removing at least a portion of the polar impurities in the sucralose mixture by mixing the sucralose mixture with an alcohol solution;
- removing at least a portion of the non-polar impurities in a one or more step purification procedure comprising mixing the sucralose mixture with an aqueous-organic solvent mixture to yield an increased purity sucralose mixture;
- and,
- crystallizing with seeding on the increased purity sucralose solution to obtain crystalline sucralose.
A process for purifying a sucralose mixture comprising sucralose, polar impurities and non-polar impurities, the process comprising:
- contacting the sucralose mixture with an alcohol solution to form a first increased purity sucralose solution;
- and,
- contacting the first increased purity sucralose solution with an aqueous-organic mixture to form a second increased purity sucralose solution, wherein the polar and non-polar impurities comprise less than 3% of the second increased purity sucralose solution.
A process for crystallizing partially purified sucralose, the process comprising:
- adding an aqueous organic solvent to the partially purified sucralose to form a reaction mixture;
- maintaining the reaction mixture at a temperature of between 40 and 90° C.;
- cooling the reaction mixture to a temperature of between 15 and 30° C.;
- seeding the reaction mixture at a temperature between 30° C. to 5° C. with an amount of pure crystalline sucralose, the amount of pure crystalline sucralose being from 0.0001% to 10% of the amount of sucralose by weight in the reaction mixture during the seeding step;
- cooling the reaction mixture to a temperature of about 0-15° C. over 0.5 hours to 24 hours;
- and,
- holding the reaction mixture at a temperature of about 0-15° C. over 0.5 hours to 24 hours to form greater than 99% pure sucralose.
A process for purifying a sucralose mixture comprising sucralose, polar impurities and non-polar impurities, the process comprising:
- contacting the sucralose mixture with an alcohol solution to form an increased purity sucralose solution;
- and,
- crystallizing the increased purity sucralose solution to form crystalline sucralose comprising at least 99% sucralose.
A process for purifying a sucralose mixture comprising sucralose, polar impurities and non-polar impurities, the process comprising:
- contacting the sucralose mixture with an aqueous-organic mixture to form an increased purity sucralose solution;
- and,
- crystallizing the increased purity sucralose solution to form crystalline sucralose comprising at least 99% sucralose.
Dependencies are inferred from the claim text.