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AssigneeHisamitsu Pharmaceutical Co., Inc.
InventorsShuji Sato, Takeshi Goto, Norifumi Tanida, Tatsuya Meno, Takaaki Yoshinaga, Keishi Yonemura
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A medicinal oral preparation to be delivered to the large intestine comprising a core containing a pharmacologically active ingredient, an inner layer containing one or more cationic polymers and an outer layer containing one or more anionic polymers whereby the core is coated, which is designed so that, in a disintegration test successively consisting of a vertical movement for 2 hours in a first solution of pH 1.2, a vertical movement for 2 hours in a second solution of pH 7.4 and a vertical movement in a third solution of pH 6.4, the average disintegration initiation point and the average disintegration completion point each falls within a period from 35 minutes to 130 minutes after starting the vertical movement in the third solution. Namely, a medicinal oral preparation to be delivered to the large intestine, a medicinal oral preparation for treating colon cancer and a medicinal oral preparation for treating colitis which would not disintegrate in the stomach or small intestine but begin to disintegrate after attaining the large intestine and surely complete the disintegration while remaining in the large intestine.
A medicinal oral preparation for colon delivery comprising a core containing a pharmacologically active component and, covering the core, an inner layer containing one or more cationic polymers and an outer layer containing one or more anionic polymers, the preparation being designed so that, in a disintegration test comprising vertical movement for 2 hours in a first solution of pH 1.2, subsequent vertical movement for 2 hours in a second solution of pH 7.4, and final vertical movement in a third solution of pH 6.4, the average disintegration initiation time and the average disintegration completion time each fall within a period from 35 min to 130 min after starting the vertical movement in the third solution.
A medicinal oral preparation for treating colon cancer comprising a core containing 10 to 70 wt % of fluorouracil and, covering the core, an inner layer containing one or more cationic polymers and an outer layer containing one or more anionic polymers.
A medicinal oral preparation for treating colitis comprising a core containing 0.5 to 10 wt % of budesonide and, covering the core, an inner layer containing one or more cationic polymers and an outer layer containing one or more anionic polymers.
Dependencies are inferred from the claim text.