Materials and methods for drug delivery and uptake

A method for sequestering a lipophilic agent within a patient comprising administering an effective amount of core-shell particles to the patient, wherein the core-shell particles comprise:

• (a) a shell, wherein the shell comprises calcium carbonate;
• (b) a core;
• and
• (c) an intermediate layer between the shell and the core, wherein the intermediate layer comprises an amphiphilic compound, and wherein the core and the intermediate layer are surrounded by the shell.

A method for sequestering a lipophilic agent from the surrounding environment comprising contacting an effective amount of core-shell particles with the lipophilic agent, wherein the core-shell particles comprise:

• (a) a shell, wherein the shell comprises calcium carbonate;
• (b) a core;
• and
• (c) an intermediate layer between the shell and the core, wherein the intermediate layer comprises an amphiphilic compound, and wherein the core and the intermediate layer are surrounded by the shell.

A method for delivering a biologically active agent to a patient comprising administering an effective amount of core-shell particles to the patient, wherein the core-shell particles comprise:

• (a) a shell, wherein the shell comprises calcium carbonate;
• (b) a core, wherein said core comprises a biologically active agent;
• and
• (c) an intermediate layer between the shell and said core, wherein said intermediate layer comprises an amphiphilic compound, and wherein said core and said intermediate layer are surrounded by said shell.