Pharmaceutical compositions for lipophilic drugs
AssigneePliva, Inc. (formerly known as Sidmak Laboratories, Inc.)
InventorsVinayak Bhalani, Satishchandra Patel
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Abstract
Stable solutions of lipophilic drugs, such as cyclosporin, forming a polar lipid self-emulsifying drug delivery system. The solutions can include lipophilic drugs, such as cyclosporin, dissolved in a polar lipid, such as having a C6-C12 fatty acid monoglyceride content of at least about 50%, surfactants and triglycerides. The composition forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.
Claims19
A composition for oral administration comprising:
- a cyclosporin and a carrier medium comprising a combination of two or more surfactants;
- wherein the combination of surfactants are selected to cause the composition, on contact with an aqueous phase, to spontaneously form a clear, fine emulsion.
A composition for oral administration comprising:
- 1) a cyclosporin and a carrier medium comprising
- 2) a fatty acid ester, and
- 3) a surfactant,
- wherein the composition, on contact with an aqueous phase, is capable of spontaneously forming a clear, fine emulsion.
A composition for oral administration comprising:
- a cyclosporin and a carrier medium;
- wherein the carrier medium is selected to cause the composition, on contact with an aqueous phase, to spontaneously form a clear, fine emulsion and,
- wherein the carrier medium is selected to cause the composition to form an emulsion of mean particle size of less than about 50 nm.
Dependencies are inferred from the claim text.