Transdermal systems having control delivery system
AssigneeMylan Technologies, Inc.
InventorsKristin Jackson, Kenneth Miller, Pavan Bhat
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Abstract
Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.
Claims42
A transdermal delivery system for delivering an active agent to the skin or mucosa of a patient comprising a backing layer, a polymer membrane disposed within said backing layer, an adhesive layer for attaching said transdermal delivery system to said skin or mucosa of said patient, and a releasable layer for covering said adhesive layer prior to attachment of said transdermal delivery system to said skin or mucosa of said patient, said polymer membrane impregnated with a predetermined amount of a fluid medium for altering the rate of transmission of said active agent through said polymer membrane to said skin or mucosa of said patient, said predetermined amount of said fluid medium being substantially greater than the amount of said fluid medium retained by said polymer membrane upon drying of said polymer membrane.
A transdermal delivery system for delivering an active agent to the skin or mucosa of a patient comprising a backing layer, a polymer membrane disposed within said backing layer, an adhesive layer for attaching said transdermal delivery system to said skin or mucosa of said patient, a releasable layer for covering said adhesive layer prior to attachment of said transdermal delivery system to said skin or mucosa of said patient, and a fluid medium distributed between said adhesive layer and said polymer membrane in a manner such that between about 25% and 100% of said fluid medium is disposed in said polymer membrane.
A method for manufacturing a transdermal delivery system for delivering an active agent to a patient comprising
- preparing an adhesive layer for attaching said transdermal delivery system to the skin or mucosa of said patient,
- providing a polymer membrane,
- impregnating said polymer membrane with a predetermined amount of a fluid medium for altering the rate of transmission of said active agent through said polymer membrane to said skin or mucosa of said patient,
- drying said adhesive layer without drying said polymer membrane,
- applying said adhesive layer to said impregnated polymer membrane,
- providing a backing layer and incorporating said adhesive layer and said polymer membrane into said backing layer, and
- providing a releasable liner adjacent to and protecting said adhesive layer prior to application of said transdermal delivery system to said skin or mucosa of said patient.
Dependencies are inferred from the claim text.