Nanoparticle coating for drug delivery
OwnerSi-Shen Fenginventor
Life of this patent
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Abstract
Coatings for drug delivery. In particular, coatings comprising nanoparticles loaded with at least one drug, on implants such as stents, to deliver drugs at the sites of implantation.
Claims23
A coating comprising at least one type of nanoparticle, wherein the at least one type of nanoparticle is emulsified by vitamin E TPGS and loaded with at least one drug.
An implant coated with at least one coating, the coating comprising at least one type of nanoparticle, wherein the at least one type of nanoparticle is emulsified by vitamin E TPGS and loaded with at least one drug.
A process of coating an implant, the process comprising:
- (a) providing an implant;
- (b) providing a lipid monolayer comprising at least one type of nanoparticle, the nanoparticle being emulsified by vitamin E TPGS and loaded with at least one drug;
- and
- (c) coating the implant with the lipid monolayer.
A method of controlling and/or reducing minimize restenosis and/or multi-drug resistence in a subject receiving a cardiovascular stent, the method comprising implanting a cardiovascular stent coated with at least one coating comprising at least one type of nanoparticle made of a biodegradeable and/or bioresorbable polymer, the at least one type of nanoparticle being emulsified by vitamin E TPGS and loaded with paclitaxel.
Dependencies are inferred from the claim text.