Back to results
US 2006/0188542 A1Published application
Implant improving local bone formation
OwnerJohn Bobyn, Michael Tanzerinventors
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerJohn Bobyn, Michael Tanzerinventors
Estimating the term…
A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a second phase gradually releases a second quantity of the active agent, whereby bone formation stimulated by the active agent is modulated. In one embodiment, a porous implant comprises a porous portion coated with a calcium phosphate compound and which is contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to the calcium phosphate at the surface of the porous portion and to form bisphosphonate molecules being non-chemically attached inside the pores of the porous portion. The non-chemically attached bisphosphonate molecules are released in the subject at a rate greater than that of the chemically bound bisphosphonate layer.
A porous implant comprising a porous portion coated with a calcium phosphate compound, said implant having been contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to said calcium phosphate compound at the surface of said portion and bisphosphonate molecules being non-chemically attached inside pores of said portion, said non-chemically attached bisphosphonate molecules being burst-releasable in a subject upon contact with body fluids and said chemically bound bisphosphonate layer being slowly releasable in said subject upon contact with said body fluids.
A porous bone implant comprising a porous portion coated with a calcium phosphate compound on an outer surface thereof and having a bisphosphonate compound applied to said porous portion to form a bisphosphonate layer chemically bound to said calcium phosphate on said outer surface of said porous portion, said bisphosphonate layer being releasable from the implant to promote bone formation around and/or within said implant when implanted in said subject.
A biocompatible bone implant comprising a bone growth stimulating portion having at least a first region with a calcium phosphate coating thereon and at least a second region free of said calcium phosphate, said bone growth stimulating portion having a bisphosphonate compound applied thereto to form a bisphosphonate layer chemically bound to said calcium phosphate over said first region and bisphosphonate molecules being non-chemically attached to said bone growth stimulating portion over said second region, wherein said bisphosphonate compound is released from said first and second regions at different rates when said implant is installed within a subject.
A biocompatible bone implant comprising a bone growth stimulating active agent on at least a portion thereof, said active agent being locally deliverable to bone proximate said implant in at least a two-phased release scheme, wherein a first phase rapidly releases a first quantity of said active agent and at least a second phase gradually releases a second quantity of said active agent, whereby bone formation stimulated by said active agent is modulated.
Dependencies are inferred from the claim text.