Dispersions for the formulation of slightly or poorly soluble agents
AssigneeAbbott GmbH & Co. KG
InventorRainer Muller
Life of this patent
Estimating the term…
Abstract
The invention provides a dispersion having an oily phase, an aqueous phase, in the form of an oil-in-water emulsion or a water-in-oil emulsion, and at least one active ingredient that is only slightly or with difficulty soluble in the oily phase and the aqueous phase. The dispersion is free from toxicologically dangerous organic solvents. The dispersion contains the active ingredient dissolved in a quantity that is greater than the quantity which results additively from its maximum solubility in the oily and the aqueous phase of the emulsion prior to forming the emulsion.
Claims73
Dispersion which comprises:
- an oily phase;
- an aqueous phase, in the form of an oil-in-water emulsion or a water-in-oil emulsion;
- and
- at least one active ingredient that is only slightly or with difficulty soluble in the oily phase and the aqueous phase, wherein the dispersion is free from toxicologically dangerous organic solvents and contains the active ingredient dissolved in a quantity that is greater than the quantity which results additively from its maximum solubility in the oily and the aqueous phase of the emulsion.
16-18. (canceled)
67-142. (canceled)
(canceled)
(canceled)
Dispersions in form of an oil-in-water emulsion comprising:
- an oil phase;
- a water phase;
- one or more surfactants or stabilizers;
- and
- one or more drugs being only slightly or poorly soluble in the water and in the oil, the dispersions are supersaturated and contain an incorporated amount of the drug in dispersion that is higher than the additive solubility calculated from the drug solubility in the oil and water phases of the dispersion, and the dispersions are organic solvent-free.
Dependencies are inferred from the claim text.