Methods for diagnosing and treating chronic tonsillitis
OwnerZhiheng Pei, Gurdip Sidhu +4inventors
InventorsZhiheng Pei, Gurdip Sidhu, Liying Yang, Pranil Chandra, Xiaohua Lu, Anna Pei
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Abstract
The invention relates to diagnostic methods, therapeutic methods and kits for diagnosing and treating chronic adenotonsillar tonsillitis and adenotonsillar hypertrophy as well as vaccines for preventing chronic adenotonsillar tonsillitis and adenotonsillar hypertrophy.
Claims38
An isolated Fusobacterium nucleatum corresponding to the isolates Fusobacterium nucleatum ssp nucleatum (ATCC 25586) or Fusobacterium nucleatum spp vincentii (ATCC 49256) deposited with the American Type Culture Collection (ATCC).
A method of diagnosing chronic adenotonsillar hypertrophy and tonsillitis comprising detecting the presence of one or more bacteria selected from the group consisting of F. nucleatum and T. denticola in a biological sample.
A method according to claim 3 wherein the biological sample is selected from the group consisting of blood or blood serum, sputum, saliva, urine.
A method for treating chronic adenotonsillar hypertrophy and tonsillitis comprising administering a pharmaceutically effective amount of an antibiotic capable of eradicating F. nucleatum or T. denticola.
A method for treating chronic adenotonsillar hypertrophy and tonsillitis comprising removing “sulfur granules” from hypertrophic tonsils.
A kit for diagnosing chronic adenotonsillar hypertrophy and tonsillitis comprising an agent capable of detecting the presence of one or more bacteria selected from the group consisting of F. nucleatum and T. denticola in a biological sample.
A vaccine for preventing chronic adenotonsillar hypertrophy and tonsillitis due to F. nucleatum or T. denticola comprising an agent capable of inducing an immune response to F. nucleatum or T. denticola.
Dependencies are inferred from the claim text.