Peptides, antibodies, and methods for the diagnosis of SARS
OwnerTo Cheung, Mun Au +5inventors
InventorsTo Cheung, Mun Au, Wing Lo, Ka To, Chui Chow, Tsz Tracy Tam, Chun Wu
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Abstract
The present invention discloses 27 immunoreactive peptides and antibodies immunologically reactive with said peptides. Such peptides and antibodies can be used for diagnosis of SARS-CoV infection as well as for preparing vaccination against SARS-CoV or a closely related coronaviruses.
Claims25
An immunoreactive peptide comprising an amino acid sequence that is at least 80% identical to a peptide selected from the group consisting of SEQ ID NOs. 1-27.
A diagnostic kit for diagnosing the presence of the SARS-CoV virus or fragments thereof comprising an antibody immunological reactive with the SARS CoV virus and capable of forming an antigen-antibody complex therewith.
A method for inducing an immune response, comprising administering a peptide comprising an amino acid sequence that is at least 80% identical to a peptide selected from the group consisting of SEQ ID NOs. 1-27.
A genetic vector comprising a nucleotide sequence selected from the group consisting of a nucleotide sequence encoding a peptide comprising one of SEQ ID NOs. 1-27, a peptide consisting essentially of one of SEQ ID NOs. 1-27, and a peptide consisting of one of SEQ ID NOs. 1-27.
A genetic vector comprising a nucleotide sequence encoding a peptide having an amino acid sequence that is at least 80% identical to a peptide selected from the group consisting of a peptide comprising one of SEQ ID NOs. 1-27, consisting essentially of SEQ ID NOs. 1-27, and a peptide consisting of one of SEQ ID NOs. 1-27.
A micro-organism having a genetic composition comprising a nucleic acid sequence encoding a peptide, said peptide having an amino acid sequence that is at least 80% identical to a peptide selected from the group consisting of a peptide comprising one of SEQ ID NOs. 1-27, a peptide consisting essentially of one of SEQ ID NOs. 1-27, and a peptide consisting of one of SEQ ID NOs. 1-27.
Dependencies are inferred from the claim text.