Methods and compositions for modulating angiogenesis
OwnerStanley Cohen, Chih-Jian Lihinventors
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Abstract
Methods and compositions for modulating angiogenesis in a subject are provided. Aspects of the invention include administering an effective amount of a TXR1 modulatory agent, e.g., a TXR1 agonist or antagonist, to a subject. Embodiments of the methods find use in a variety of different applications, including the inhibition of tumor growth and the treatment of disease conditions characterized by tumor presence.
Claims25
A method of modulating angiogenesis in a subject, said method comprising:
- administering to said subject an effective amount of a TXR1 modulatory agent.
A method of inhibiting tumor growth in a subject, said method comprising:
- administering to said subject an effective amount of a TXR1 antagonist.
A pharmaceutical composition comprising an effective amount of a TXR1 modulatory agent in a pharmaceutical acceptable vehicle.
A kit comprising:
- a TXR1 modulatory agent;
- and
- instructions for using said agent to modulate angiogenesis.
Dependencies are inferred from the claim text.