Intranasal administration of active agents to the central nervous system
OwnerHanne Bentz, Beth Hill +2inventors
InventorsHanne Bentz, Beth Hill, Catherine Lucas, William Frey
Life of this patent
Estimating the term…
Abstract
A method for delivering a polypeptide to the central nervous system of a mammal is provided. The method involves attaching the polypeptide to an antibody or an antibody fragment and administering the fusion polypeptide intranasally, for delivery to the central nervous system. Methods of treatment are also provided, where a therapeutically effective amount of the composition is delivered to the nasal cavity of a mammal.
Claims29
A method of delivering a therapeutic composition to the central nervous system of a mammal, comprising intranasally administering a therapeutically effective amount of a composition comprised of a therapeutic polypeptide and an antibody fragment.
A method for targeting a polypeptide to the central nervous system, comprising
- attaching an antibody or antibody fragment to the polypeptide to form a fusion polypeptide;
- and
- administering the fusion polypeptide intranasally.
A method of treatment, comprising intranasally administering to a mammal a therapeutically effective amount of a composition comprised of a polypeptide linked to an antibody fragment.
A method of treatment, comprising intranasally administering to a mammal a therapeutic composition comprising a therapeutically effective amount of an antibody or an antibody fragment.
Dependencies are inferred from the claim text.