Use of nuclear material to therapeutically reprogram differentiated cells
AssigneePrimeGen Biotech LLC
InventorsChauncey Sayre, Francisco Silva
Life of this patent
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Abstract
Methods are provided for therapeutically reprogramming differentiated cells with nuclear extracts from pluripotent stem cells to generate a pluripotent epigenetic state in the differentiated cells. Additionally, therapeutically programmed cells for therapeutic use in patients are provided. Therapeutically programmed cells are stem cells which have been matured such that they represent either a more differentiated state or a less differentiated state after contact with stimulatory factors.
Claims20
A method for therapeutically reprogramming differentiated cells to yield pluripotent cells comprising:
- isolating a differentiated cell;
- preparing a nuclear extract from a pluripotent stem cell;
- and
- incubating said differentiated cells with said nuclear extract to form reprogrammed pluripotent cells.
A pluripotent cell useful for regenerative therapy in a patient in need thereof comprising:
- a differentiated cell therapeutically reprogrammed by exposure to a nuclear extract.
Dependencies are inferred from the claim text.