Wound care polymer compositions and methods for use thereof

A multilayer bioactive wound dressing comprising:

• a non-stick layer comprising a biodegradable hydrogel;
• a supporting layer comprising a biodegradable polymer, wherein the supporting layer overlies the non-stick layer;
• and
• at least one wound healing agent that produces a wound healing effect in situ dispersed within the polymer, the hydrogel, or both,
• wherein the polymer is a PEA having a chemical formula described by structural formula (I),
• wherein n ranges from about 5 to about 150;
• R1 is independently selected from residues of α,ω-bis(4-carboxyphenoxy)-(C1-C8) alkane, 3,3′-(alkanedioyldioxy)dicinnamic acid or 4,4′(alkanedioyldioxy)dicinnamic acid, (C2-C20) alkylene, (C2-C20) alkenylene or saturated or unsaturated residues of therapeutic di-acids;
• the R3s in individual n monomers are independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C10) aryl (C1-C6) alkyl, and —(CH2)2S(CH3);
• and R4 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, (C2-C8) alkyloxy, (C2-C20) alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II), and combinations thereof, (C2-C20) alkylene, (C2-C20) alkenylene, saturated or unsaturated therapeutic di-acid residues, and combinations thereof;
• or a PEA having a chemical formula described by structural formula III,
• wherein n ranges from about 5 to about 150, m ranges about 0.1 to 0.9:
• p ranges from about 0.9 to 0.1;
• wherein R1 is independently selected from residues of α,ω-bis(4-carboxyphenoxy)-(C1-C8) alkane, 3,3′(alkanedioyldioxy)dicinnamic acid or 4,4′(alkanedioyldioxy)dicinnamic acid, (C2-C20) alkylene, (C2-C20) alkenylene or a saturated or unsaturated residues of therapeutic di-acids;
• each R2 is independently hydrogen, (C1-C12) alkyl or (C6-C10) aryl or a protecting group;
• the R3s in individual m monomers are independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C10) aryl (C1-C6) alkyl, and —(CH2)2S(CH3);
• and R4 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, (C2-C8) alkyloxy, (C2-C20) alkylene, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II), and combinations thereof, and residues of saturated or unsaturated therapeutic diols;
• or a poly(ester urethane) (PEUR) having a chemical formula described by structural formula (IV),
• wherein n ranges from about 5 to about 150;
• wherein R3s in independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C10) aryl(C1-C6) alkyl, and —(CH2)2S(CH3);
• R4 is selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene or alkyloxy, and bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II);
• and R6 is independently selected from (C2-C20) alkylene, (C2-C20) alkenylene or alkyloxy, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of general formula (II), a residue of a saturated or unsaturated therapeutic diol, and mixtures thereof;
• or a PEUR having a chemical structure described by general structural formula (V),
• wherein n ranges from about 5 to about 150, m ranges about 0.1 to about 0.9:
• p ranges from about 0.9 to about 0.1;
• R2 is independently selected from hydrogen, (C6-C10)aryl(C1-C6) alkyl, or a protecting group;
• the R3s in an individual m monomer are independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C10) aryl(C1-C6) alkyl, and —(CH2)2S(CH3);
• R4 is selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene or alkyloxy, and bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (II);
• and R6 is independently selected from (C2-C20) alkylene, (C2-C20) alkenylene or alkyloxy, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of general formula (II), a residue of a saturated or unsaturated therapeutic diol, and mixtures thereof;
• or a poly(ester urea) (PEU) having a chemical formula described by general structural formula (VI),
• wherein n is about 10 to about 150;
• each R3s within an individual n monomer are independently selected from hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C10) aryl (C1-C6)alkyl, and —(CH2)2S(CH3);
• R4 is independently selected from (C2-C20) alkylene, (C2-C20) alkenylene, (C2-C8) alkyloxy (C2-C20) alkylene, a residue of a saturated or unsaturated therapeutic diol;
• or a bicyclic-fragment of a 1,4:3,6-dianhydrohexitol of structural formula (II), and mixtures thereof;
• or a PEU having a chemical formula described by structural formula (VII),
• wherein m is about 0.1 to about 1.0;
• p is about 0.9 to about 0.1;
• n is about 10 to about 150;
• each R is independently hydrogen, (C1-C12) alkyl or (C6-C10) aryl;
• the R3s within an individual m monomer are independently selected from hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C10) aryl (C1-C6)alkyl, and —(CH2)2S(CH3);
• each R4 is independently selected from (C2-C20) alkylene, (C2-C20) alkenylene, (C2-C8) alkyloxy (C2-C20) alkylene, a residue of a saturated or unsaturated therapeutic diol;
• or a bicyclic-fragment of a 1,4:3,6-dianhydrohexitol of structural formula (II), and mixtures thereof.