HAS-active ingredient conjugates
AssigneeFresenius Kabi Deutschland GMBH, a Germany corporation
InventorsKlaus Sommermeyer, Wolfram Eichner, Sven Frie, Cornelius Jungheinrich, Roland Scharpf, Katharina Lutterbeck
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Abstract
The invention relates to compounds comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
Claims23
1-72. (canceled)
A process for the preparation of a nucleic acid conjugate, the method comprising coupling HAS and a nucleic acid in a reaction medium, wherein the reaction medium is (a) water or (b) a mixture of water with an organic solvent, the mixture comprising at least 10 weight-% water.
Dependencies are inferred from the claim text.