Process for the production of an abuse-proofed dosage form
OwnerElisabeth Arkenau-Maric, Johannes Bartholomausinventors
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Abstract
The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
Claims25
A process for the production of a solid dosage form with at least reduced potential for abuse where
- a) a formulation mixture containing at least one active ingredient with potential for abuse (A) and at least one synthetic or natural polymer (C), which exhibits a breaking strength of at least 500 N is uniformly moistened with at least a sufficient quantity of a solvent for the polymer (C) to uniformly moisten the mixture,
- b) optionally dividing the mixture from step a) into sub-portions,
- c) drying the sub-portion(s) from step b) or the mixture from step a) and
- d) shaping the dried sub-portion or mixture from step c) to yield the dosage form.
Dependencies are inferred from the claim text.