Radiolabeled gallium complexes, methods for synthesis and use for PET imaging of EGFR expression in malignant tumors
OwnerVladimir Tolmachev, Bengt Langstrom +2inventors
InventorsVladimir Tolmachev, Bengt Langstrom, Asa Sundberg, Irina Velikyan
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Abstract
Methods for labeling synthesis of radiolabeled gallium complex by microwave activation are provided. The resultant gallium-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). A method for imaging EGFR overexpression in tumors using PET is also provided.
Claims17
A method for labeling synthesis of radiolabeled gallium complex, comprising:
- (a) providing a 68Ga3+ radioisotope,
- (b) reacting said 68Ga3+ radioisotope with a chelating agent using microwave activation, and (c) collecting the resultant radiolabeled gallium complex.
A method for imaging of EGFR overexpression in tumors comprising administering a radiolabeled gallium complex to human, wherein the radiolabeled gallium complex is capable of being imaged by PET, detecting EGFR overexpression in tumors by performing PET.
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