Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
AssigneeBoard of Regents, The University of Texas System
InventorsDavid Yang, Chun Liu, Dong-Fang Yu, E. Kim
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Abstract
The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
Claims46
1-41. (canceled)
A kit for preparing a radiopharmaceutical preparation, said kit comprising one or more sealed containers, and a predetermined quantity of a bis-aminoethanethiol (BAT)-targeting ligand conjugate composition in one or more of the sealed containiners.
A reagent for preparing a scintigraphic imaging agent comprising a targeting ligand covalently linked to a bis-aminoethanethiol (BAT).
(canceled)
The kit of claim 64, wherein the tumor marker is PSA, ER, PR, CA-125, CA-199, CEA AFP, interferons, BRCA1, HER-2/neu, cytoxan, p53, or endostatin.
Dependencies are inferred from the claim text.