Isolation of a cell-specific internalizing peptide that infiltrates tumor tissue for targeted drug delivery
AssigneeBoard of Regents, The University of Texas System
InventorsFrank Hong, Gary Clayman
Life of this patent
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Abstract
The present invention provides a tumor-homing peptide that can target cancer and or tumor tissues. The peptide is uptaken by certain specific cancer cell types. The invention describes methods to achieve targeted delivery of anticancer drugs conjugated to this peptide for anticancer therapy. The invention also describes methods for using the peptide for the diagnosis and imaging of cancer and tumor tissues.
Claims29
1-15. (canceled)
A method for killing a tumor cell comprising contacting said tumor cell with a pharmaceutically acceptable composition comprising:
- a) a drug;
- and
- b) a peptide that targets said tumor cell, wherein said peptide is internalized by said tumor cell.
27-50. (canceled)
A method for killing a tumor cell comprising administering to a patient:
- a) radiotherapy;
- and
- b) a pharmaceutically acceptable composition comprising an anti-tumor compound conjugated to a peptide that targets said tumor cell, wherein said peptide is internalized by said tumor cell.
A method for killing a tumor cell comprising administering to a patient:
- a) chemotherapy;
- and
- b) a pharmaceutically acceptable composition comprising an anti-tumor compound conjugated to a peptide that targets said tumor cell, wherein said peptide is internalized by said tumor cell.
A method for killing a tumor cell comprising administering to a patient:
- a) chemotherapy;
- and
- b) a pharmaceutically acceptable composition comprising a liposome linked to a peptide that targets said tumor cell, wherein said liposome comprises an anti-tumor compound, and wherein said peptide is internalized by said tumor cell.
A method for killing a tumor cell comprising administering to a patient:
- a) surgery;
- and
- b) a pharmaceutically acceptable composition comprising an anti-tumor compound conjugated to a peptide that targets said tumor cell, wherein said peptide is internalized by said tumor cell.
A method for killing a tumor cell comprising administering to a patient:
- a) gene therapy;
- and
- b) a pharmaceutically acceptable composition comprising an anti-tumor compound conjugated to a peptide that targets said tumor cell, wherein said peptide is internalized by said tumor cell.
64-83. (canceled)
A method for killing a cancer cell comprising the steps of:
- (1) obtaining a peptide library;
- (2) individually contacting peptides of said library with members of a cell population;
- (3) assaying for endocytosis of said peptides by said members of said cell population to identify an internalizing peptide;
- (4) conjugating a drug to said peptide;
- and
- (5) administering the conjugated peptide and drug to an organism.
A method for killing a cancer cell comprising the steps of:
- (1) obtaining a peptide library;
- (2) individually contacting peptides of said library with members of a cell population;
- (3) assaying for endocytosis of said peptides by said members of said cell population to identify an internalizing peptide;
- (4) conjugating a composition for gene therapy to said peptide;
- and
- (5) administering the conjugated peptide and gene therapy composition to an organism.
Dependencies are inferred from the claim text.