Microfluidic devices with SPR sensing capabilities
AssigneeSierra Sensors GmbH
InventorsKarla Robotti, Daniel Roitman, Kevin Killeen
Life of this patent
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Abstract
A microfluidic system including a chip sensor and an SPR optical detector. The chip sensor may be made a non-transparent material, such as polyimide or silicon, allowing non-visible radiation produced by the SPR optical detector to pass through and interact with a surface plasmon generating layer on the chip sensor.
Claims26
A SPR system comprising a sensor substrate and an optical detector, said optical detector configured to generate non-visible radiation in a predetermined wavelength detection range and to direct said radiation towards the sensor substrate, at least a portion of the sensor substrate containing a surface plasmon generating film, the sensor substrate being made from a material that is not transparent to visible light but allowing for penetration of the non-visible radiation to the surface plasmon generating film.
A sensor chip comprising a substrate, at least a portion of said substrate containing a surface plasmon generating film, said sensor chip at least partially being made from a material that is not transparent to visible radiation but allowing radiation having a predetermined wavelength in at least a portion of the non-visible wavelength range to pass through the sensor chip to the film.
A method for using a microfluidic system for SPR analysis, said microfluidic system comprising a sensor chip and an optical detector, said sensor chip comprising at least one channel, at least a portion of said channel containing a surface plasmon generating film, said optical detector generating non-visible radiation in a predetermined wavelength detection range and being configured to direct said radiation towards the sensor chip, the sensor chip being made from a material that is not transparent but allowing radiation in the predetermined wavelength detection range to pass through to the surface plasmon generating film, said method comprising the steps of:
- passing a solution of interest through the channel;
- and
- passing non-visible radiation generated by the optical detector through the sensor chip towards the surface plasmon generating film.
Dependencies are inferred from the claim text.