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US 2006/0187450 A1Published application
Axial illumination for capillary electrophoresis
AssigneeApplera Corporation
InventorsRichard Reel, Eric Nordman
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Abstract
System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
Claims37
An excitation system for analyzing samples comprising:
- a non-coherent light source;
- a housing, wherein the housing transports samples and propagates light from the non-coherent light source by total internal reflection;
- and
- a coupling optical element configured to introduce light from the non-coherent light source into the housing through a wall of the housing.
1 more element
A fluorescence excitation system for analyzing samples comprising:
- a non-coherent light source;
- a housing, wherein the housing transports the samples and propagates light from the non-coherent light source;
- and
- at least one high NA optical element configured to focus light from the non-coherent light source onto an end of the housing.
1 more element
A method for exciting fluorescence of samples comprising:
- transporting a plurality of samples through a detection zone with a capillary;
- directing a non-coherent light into the capillary with a coupling optical element;
- and
- illuminating the detection zone with the non-coherent light propagating through the capillary.
1 more element
A system for analyzing samples comprising:
- a light source that provides a non-coherent excitation light;
- at least one housing, wherein the housing transports samples and propagates the non-coherent excitation light by total internal reflection;
- a coupling optical element configured to introduce the non-coherent excitation light into the at least one housing through a wall of the at least one housing;
- and
- at least one NA enhancing optical element to collect an emitted fluorescence,
- wherein the NA enhancing optical element is constructed of a first material and the housing is constructed of a second material, wherein the first material has a greater index of refraction than the second material.
3 more elements
A system for analyzing samples comprising:
- a light source that provides a non-coherent excitation light;
- at least one housing, wherein the housing transports samples and propagates the non-coherent excitation light by total internal reflection;
- a coupling optical element configured to introduce the non-coherent excitation light into the at least one housing through a wall of the at least one housing;
- and
- at least one NA enhancing optical element to collect an emitted fluorescence,
- wherein the NA enhancing optical element is constructed of a first material and the housing is constructed of a second material, wherein the first material has a greater index of refraction than the second material.
3 more elements
Dependencies are inferred from the claim text.