Ion chromatography system using catalytic gas elimination
AssigneeDionex Corporation
InventorsYan Liu, Christopher Pohl, Nebojsa Avdalovic, John Riviello, Archava Siriraks
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Abstract
A liquid chromatographic system is provided including catalytically combining hydrogen and oxygen gases in the chromatography eluent stream in a catalytic gas elimination chamber, to form water and thereby reduce the gas content in the eluent stream. Also, a liquid ion chromatographic system in which the effluent from the detector is recycled to a membrane suppressor and then is mixed with a source of eluent for recycle to the chromatographic column.
Claims26
A chromatographic method comprising the steps of:
- (a) injecting sample ionic species into an aqueous eluent stream,
- (b) chromatographically separating said sample ionic species in said eluent stream by flowing the same through chromatographic separation medium,
- (c) detecting said separated sample ionic species in said eluent stream effluent from said chromatographic medium, and
- (d) catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide, or both, in said eluent stream in a catalytic gas elimination chamber, to form water and reduce the gas content in said eluent stream.
A chromatographic method comprising:
- (a) chromatographically separating sample ionic species in an aqueous liquid eluent stream flowing through a chromatography separation medium, to form a chromatography effluent,
- (b) suppressing the chromatography effluent from step (a) by flowing it through a chromatography effluent flow channel on one side of a first ion exchange membrane in a membrane suppressor,
- (c) flowing suppressor effluent from said chromatography effluent flow channel past a flow-through detector to form a detector effluent stream,
- (d) recycling the detector effluent from step (c) to a detector effluent flow channel in said membrane suppressor on the opposite side of said first membrane from said chromatography effluent flow channel, and
- (e) mixing effluent from said detector effluent flow channel with a source of eluent and flowing the mixture to said chromatography separation medium.
A chromatography apparatus comprising:
- (a) chromatographic separation medium,
- (b) a detector,
- (c) a conduit for an aqueous liquid eluent stream providing fluid communication between said chromatographic separation medium and with said detector, and
- (d) a catalytic gas elimination chamber in fluid communication with said conduit and including a catalyst for combining hydrogen and oxygen gases, or for catalytically decomposing hydrogen peroxide, or both, in said eluent stream to form water and reduce the gas content in said eluent stream.
A chromatography apparatus comprising:
- (a) chromatographic separation medium,
- (b) a detector,
- (c) a membrane suppressor comprising a chromatographic effluent flow channel, a detector effluent flow channel and an ion exchange membrane separating said two flow channels,
- (d) a first conduit providing fluid communication between said separator medium and said membrane suppressor,
- (e) a second conduit providing fluid communication between said membrane suppressor and said detector,
- (f) a third conduit providing fluid communication between said detector and said detector effluent flow channel, and
- (g) a fourth conduit providing fluid communication between said detector effluent flow channel and said separation medium.
Dependencies are inferred from the claim text.