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US 2006/0182683 A1Published application
Methods for reduced renal uptake of protein conjugates
AssigneeCenter for Molecular Medicine and Immunology
InventorsThomas Behr, David Goldenberg
Life of this patent
Estimating the term…
Abstract
Kidney uptake of antibody fragment conjugates and protein conjugates in patients is reduced by administration to the patient of one or more compounds selected from the group consisting of D-lysine, poly-D-lysine, or poly-L-lysine, or pharmaceutically acceptable salts or carboxyl derivatives thereof.
Claims18
1-37. (canceled)
A method of increasing by at least 2-fold the pharmaceutically acceptable dosage of a protein conjugate for therapeutic or diagnostic purposes, said method comprising:
- administering to a patient one or more compounds selected from the group consisting of D-lysine, poly-lysine having a molecular weight in the range of 1-60 kD, pharmaceutically acceptable salts thereof and carboxyl derivatives thereof, wherein said protein conjugate has a molecular weight that is not greater than about 60 kD,
- wherein the pharmaceutically acceptable salt and carboxyl derivative of poly-lysine has a molecular weight in the range of 1-60 kD,
- wherein said 2-fold increase is relative to administration of said protein conjugate in the absence of administering said one or more compounds selected from the group consisting of D-lysine, poly-lysine having a molecular weight in the range of 1-60 kD, pharmaceutically acceptable salts thereof or carboxyl derivatives thereof.
Dependencies are inferred from the claim text.