Composition and method for killing of tumours
OwnerGerald Both, Trevor Lockett +6inventors
InventorsGerald Both, Trevor Lockett, Peter Molloy, Fiona Cameron, Pamela Russell, Rosetta Martiniello-Wilks, Minoo Moghaddam, Ian Smith
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Abstract
The present invention provides a method of treating a solid tumour in a subject, the method comprising the following steps (i) delivering to the solid tumour a composition comprising an engineered ovine atadenovirus; and (ii) administering a prodrug to the subject, wherein the engineered ovine atadenovirus comprises a promoter and a gene encoding an enzyme which converts the prodrug to a cytotoxic metabolite, the gene being under control of the promoter.
Claims28
A method of treating a solid tumour in a subject, the method comprising the following steps
- (i) delivering to the solid tumour a composition comprising an engineered ovine atadenovirus and a lipid;
- and
- (ii) administering a prodrug to the subject,
- wherein the engineered ovine atadenovirus comprises a promoter and a gene encoding an enzyme which converts the prodrug to a cytotoxic metabolite, the gene being under the control of the promoter.
A composition comprising
- (i) an engineered ovine atadenovirus;
- and
- (ii) a lipid,
- wherein the engineered ovine atadenovirus comprises a promoter and a gene encoding an enzyme which converts a prodrug to a cytotoxic metabolite, the gene being under the control of the promoter.
Dependencies are inferred from the claim text.