Vaccine against Gram-negative bacterial infections
AssigneeU.S. Government Dept. of the Army
InventorsApurba Bhattacharjee, Alan Cross, Jerald Sadoff, Wendell Zollinger
Life of this patent
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Abstract
A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
Claims7
1-10. (canceled)
A method of passively conferring upon a second subject protection against infection by Gram-negative bacteria or LPS-mediated pathology, comprising the steps of:
- a)actively immunizing a first subject with a vaccine comprising a non-covalent complex between purified LPS endotoxin derived from E. coli and purified outer membrane protein derived from N. meningitidis;
- b)collecting from said first subject a post-immune serum or plasma, or IgG isolated therefrom;
- and,
- c)administering to said second subject an amount of said serum or plasma or IgG isolated therefrom that is effective in conferring passive protection against a infection by Gram-negative bacteria and LPS-mediated pathology.
15-17. (canceled)
Serum, plasma or specific polyclonal antibody obtained from a subject immunized with a vaccine effective in actively immunizing a subject against infection by Gram-negative bacteria or against lipopolysaccharide (LPS) endotoxin-mediated pathology, comprising a non-covalent complex between purified LPS endotoxin derived from E. coli and purified outer membrane protein derived from N. meningitidis.
Dependencies are inferred from the claim text.