Tumour necrosis factor peptide binding antibodies
AssigneePeptech Limited
InventorsDeborah Rathjen, Roger Aston
Life of this patent
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Abstract
Provided are isolated antibodies or fragments thereof which bind a peptide consisting of residues Gly54-Leu55-Tyr56-Leu57-Ile58-Tyr59-Ser60-Gln61-Val62-Leu63-Phe64-Lys65-Gly66-Gln67-Gly68 (peptide 308) of mature human TNF-α. The antibodies and fragments thereof may be used to identify antibodies capable of binding in the region of mature human TNF-α of amino acid resides 54-68. Antibodies or fragments thereof which bind particular regions of mature human TNF-α are shown to elicit particular biological activities dependent upon the particular region wherein binding occurs.
Claims30
An isolated antibody or fragment thereof which binds a peptide consisting of residues Gly54-Leu55-Tyr56-Leu57-Ile58-Tyr59-Ser60-Gln61-Val62-Leu63-Phe64-Lys65-Gly66-Gln67-Gly68 (peptide 308) of mature human TNF-α.
A composition comprising an isolated antibody or fragment thereof which binds a peptide consisting of residues Gly54-Leu55-Tyr56-Leu57-Ile58-Tyr59-Ser60-Gln61-Val62-Leu63-Phe64-Lys65-Gly66-Gln67-Gly68 (peptide 308) of mature human TNF-α.
An isolated single chain antibody which binds a peptide consisting of residues Gly54-Leu55-Tyr56-Leu57-Ile58-Tyr59-Ser60-Gln61-Val62-Leu63-Phe64-Lys65-Gly66-Gln67-Gly68 (peptide 308) of mature human TNF-α.
A composition comprising an isolated single chain antibody which binds a peptide consisting of residues Gly54-Leu55-Tyr56-Leu57-Ile58-Tyr59-Ser60-Gln61-Val62-Leu63-Phe64-Lys65-Gly66-Gln67-Gly68 (peptide 308) of mature human TNF-α.
An isolated single domain antibody or fragment thereof which binds a peptide consisting of residues Gly54-Leu55-Tyr56-Leu57-Ile58-Tyr59-Ser60-Gln61-Val62-Leu63-Phe64-Lys65-Gly66-Gln67-Gly68 (peptide 308) of mature human TNF-α.
A composition comprising an isolated antibody or fragment thereof which binds a peptide consisting of residues Gly54-Leu55-Tyr56-Leu57-Ile58-Tyr59-Ser60-Gln61-Val62-Leu63-Phe64-Lys65-Gly66-Gln67-Gly68 (peptide 308) of mature human TNF-α.
Dependencies are inferred from the claim text.