Genes related to drug resistance
AssigneeNorthwestern University
InventorsVivtor Levenson, Natalie Motchoulskala
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Abstract
The present invention relates to genetic profiles and markers of cancers and provides systems and methods for screening drugs that are effective for specific patients and types of cancers.
Claims13
A method of detecting efficacy of chemotherapeutic agents, said method comprising detecting the expression or activity of a marker selected from the group consisting of macrophage migration inhibitory factor (MIF), prolylcarboxypeptidase, tRNA-guanine transglycosylase, and kinesin light chain (KNS2).
A method of monitoring chemotherapeutic treatment, said method comprising measuring the expression of a resistance inducing gene selected from the group consisting of macrophage migration inhibitory factor (MIF), prolylcarboxypeptidase, tRNA-guanine transglycosylase, and kinesin light chain (KNS2) in a sample obtained from a subject undergoing chemotherapy.
A method of screening compounds, comprising:
- a) providing a cell expressing a a resistance inducing gene selected from the group consisting of macrophage migration inhibitory factor (MIF), prolylcarboxypeptidase, tRNA-guanine transglycosylase, and kinesin light chain (KNS2);
- and
- b) exposing said cell to a test compound.
Dependencies are inferred from the claim text.